AustralieFrV1, Main, Exploration, bibRecord, 005776

Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3

Identifieur interne : 005776 ( Main/Exploration ); précédent : 005775; suivant : 005777

Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3

Auteurs : Alexander J. Thompson [États-Unis] ; Keyur Patel [États-Unis] ; Wan-Long Chuang [Taïwan] ; Eric J. Lawitz [États-Unis] ; Maribel Rodriguez-Torres [États-Unis] ; Vinod K. Rustgi [États-Unis] ; Robert Flisiak [Pologne] ; Stephen Pianko [Australie] ; Moises Diago [Espagne] ; Sanjeev Arora [États-Unis] ; Graham R. Foster [Royaume-Uni] ; Michael Torbenson [États-Unis] ; Yves Benhamou [France] ; David R. Nelson [États-Unis] ; Mark S. Sulkowski [États-Unis] ; Stefan Zeuzem [Allemagne] ; Erik Pulkstenis [États-Unis] ; G. Mani Subramanian [États-Unis] ; John G. Mchutchison [États-Unis]

Source :

Gut [ 0017-5749 ] ; 2012.

RBID : Pascal:12-0034291

Descripteurs français

Pascal (Inist)
- Insulinorésistance, Hépatite virale C, Clairance, Génotype, Typage, Gastroentérologie.

English descriptors

KwdEn :
- Clearance, Gastroenterology, Genotype, Insulin resistance, Typing, Viral hepatitis C.

Abstract

Objectives Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. Methods 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. Results Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33% vs 27%; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10%; p<0.001), but not in genotype 1 non-responders or those with genotype 2/3. Multivariate analysis indicated that SVR was associated with a significant reduction in mean HOMA-IR in patients with genotype 1 (p=0.004), but not in those with genotype 2/3, which was independent of body mass index, alanine transaminase, γ-glutamyl transpeptidase and lipid level changes. Conclusions SVR is associated with a reduction in HOMA-IR in patients with HCV genotype 1 but not in those with genotype 2/3. Genotype 1 may have a direct effect on the development of IR, independent of host metabolic factors, and may be partially reversed by viral eradication.

Affiliations:

Allemagne, Australie, Espagne, France, Pologne, Royaume-Uni, Taïwan, États-Unis
Angleterre, Caroline du Nord, Catalogne, District de Darmstadt, Floride, Grand Londres, Hesse (Land), Maryland, Texas, Virginie, Île-de-France
Barcelone, Francfort-sur-le-Main, Londres, Paris
Université de Londres

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Curation: 004816
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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3</title>
<author><name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J." last="Thompson">Alexander J. Thompson</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Duke Clinical Research Institute, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
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<author><name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Duke Clinical Research Institute, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
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<author><name sortKey="Chuang, Wan Long" sort="Chuang, Wan Long" uniqKey="Chuang W" first="Wan-Long" last="Chuang">Wan-Long Chuang</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Kaohsiung Medical University Hospital, Kaohsiung Medical University</s1>
<s2>Kaohsiung</s2>
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<country>Taïwan</country>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
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<author><name sortKey="Lawitz, Eric J" sort="Lawitz, Eric J" uniqKey="Lawitz E" first="Eric J." last="Lawitz">Eric J. Lawitz</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Alamo Medical Research</s1>
<s2>San Antonio, Texas</s2>
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<author><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name>
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<author><name sortKey="Diago, Moises" sort="Diago, Moises" uniqKey="Diago M" first="Moises" last="Diago">Moises Diago</name>
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<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Johns Hopkins Center for Viral Hepatitis</s1>
<s2>Baltimore, Maryland</s2>
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<author><name sortKey="Benhamou, Yves" sort="Benhamou, Yves" uniqKey="Benhamou Y" first="Yves" last="Benhamou">Yves Benhamou</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Hôpital Pitié-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
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<settlement type="city">Paris</settlement>
</placeName>
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<author><name sortKey="Nelson, David R" sort="Nelson, David R" uniqKey="Nelson D" first="David R." last="Nelson">David R. Nelson</name>
<affiliation wicri:level="2"><inist:fA14 i1="13"><s1>University of Florida</s1>
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<country>États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sulkowski, Mark S" sort="Sulkowski, Mark S" uniqKey="Sulkowski M" first="Mark S." last="Sulkowski">Mark S. Sulkowski</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Johns Hopkins Center for Viral Hepatitis</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>J W Goethe University Hospital</s1>
<s2>Frankfurt</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pulkstenis, Erik" sort="Pulkstenis, Erik" uniqKey="Pulkstenis E" first="Erik" last="Pulkstenis">Erik Pulkstenis</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Human Genome Sciences Inc</s1>
<s2>Rockville, Maryland</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G. Mani" last="Subramanian">G. Mani Subramanian</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Human Genome Sciences Inc</s1>
<s2>Rockville, Maryland</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G." last="Mchutchison">John G. Mchutchison</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Duke Clinical Research Institute, Duke University Medical Center</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Gut</title>
<title level="j" type="abbreviated">Gut</title>
<idno type="ISSN">0017-5749</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Gut</title>
<title level="j" type="abbreviated">Gut</title>
<idno type="ISSN">0017-5749</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clearance</term>
<term>Gastroenterology</term>
<term>Genotype</term>
<term>Insulin resistance</term>
<term>Typing</term>
<term>Viral hepatitis C</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Insulinorésistance</term>
<term>Hépatite virale C</term>
<term>Clairance</term>
<term>Génotype</term>
<term>Typage</term>
<term>Gastroentérologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objectives Genotype-specific associations between hepatitis C virus (HCV) and insulin resistance (IR) have been described, but a causal relationship remains unclear. This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy. Methods 2255 treatment-naive patients with chronic HCV genotype 1 or 2/3 were enrolled in two phase 3 trials of albinterferon alpha-2b versus pegylated interferon alpha-2a for 48 or 24 weeks, respectively. IR was measured before treatment and 12 weeks after treatment using homeostasis model assessment (HOMA)-IR. Results Paired HOMA-IR measurements were available in 1038 non-diabetic patients (497 with genotype 1; 541 with genotype 2/3). At baseline the prevalence of HOMA-IR >3 was greater in patients with genotype 1 than 2/3 (33% vs 27%; p=0.048). There was a significant reduction in the prevalence of IR in patients with genotype 1 achieving SVR (δ 10%; p<0.001), but not in genotype 1 non-responders or those with genotype 2/3. Multivariate analysis indicated that SVR was associated with a significant reduction in mean HOMA-IR in patients with genotype 1 (p=0.004), but not in those with genotype 2/3, which was independent of body mass index, alanine transaminase, γ-glutamyl transpeptidase and lipid level changes. Conclusions SVR is associated with a reduction in HOMA-IR in patients with HCV genotype 1 but not in those with genotype 2/3. Genotype 1 may have a direct effect on the development of IR, independent of host metabolic factors, and may be partially reversed by viral eradication.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Taïwan</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Caroline du Nord</li>
<li>Catalogne</li>
<li>District de Darmstadt</li>
<li>Floride</li>
<li>Grand Londres</li>
<li>Hesse (Land)</li>
<li>Maryland</li>
<li>Texas</li>
<li>Virginie</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Francfort-sur-le-Main</li>
<li>Londres</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Londres</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Thompson, Alexander J" sort="Thompson, Alexander J" uniqKey="Thompson A" first="Alexander J." last="Thompson">Alexander J. Thompson</name>
</region>
<name sortKey="Arora, Sanjeev" sort="Arora, Sanjeev" uniqKey="Arora S" first="Sanjeev" last="Arora">Sanjeev Arora</name>
<name sortKey="Lawitz, Eric J" sort="Lawitz, Eric J" uniqKey="Lawitz E" first="Eric J." last="Lawitz">Eric J. Lawitz</name>
<name sortKey="Mchutchison, John G" sort="Mchutchison, John G" uniqKey="Mchutchison J" first="John G." last="Mchutchison">John G. Mchutchison</name>
<name sortKey="Nelson, David R" sort="Nelson, David R" uniqKey="Nelson D" first="David R." last="Nelson">David R. Nelson</name>
<name sortKey="Patel, Keyur" sort="Patel, Keyur" uniqKey="Patel K" first="Keyur" last="Patel">Keyur Patel</name>
<name sortKey="Pulkstenis, Erik" sort="Pulkstenis, Erik" uniqKey="Pulkstenis E" first="Erik" last="Pulkstenis">Erik Pulkstenis</name>
<name sortKey="Rodriguez Torres, Maribel" sort="Rodriguez Torres, Maribel" uniqKey="Rodriguez Torres M" first="Maribel" last="Rodriguez-Torres">Maribel Rodriguez-Torres</name>
<name sortKey="Rustgi, Vinod K" sort="Rustgi, Vinod K" uniqKey="Rustgi V" first="Vinod K." last="Rustgi">Vinod K. Rustgi</name>
<name sortKey="Subramanian, G Mani" sort="Subramanian, G Mani" uniqKey="Subramanian G" first="G. Mani" last="Subramanian">G. Mani Subramanian</name>
<name sortKey="Sulkowski, Mark S" sort="Sulkowski, Mark S" uniqKey="Sulkowski M" first="Mark S." last="Sulkowski">Mark S. Sulkowski</name>
<name sortKey="Torbenson, Michael" sort="Torbenson, Michael" uniqKey="Torbenson M" first="Michael" last="Torbenson">Michael Torbenson</name>
</country>
<country name="Taïwan"><noRegion><name sortKey="Chuang, Wan Long" sort="Chuang, Wan Long" uniqKey="Chuang W" first="Wan-Long" last="Chuang">Wan-Long Chuang</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Flisiak, Robert" sort="Flisiak, Robert" uniqKey="Flisiak R" first="Robert" last="Flisiak">Robert Flisiak</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Pianko, Stephen" sort="Pianko, Stephen" uniqKey="Pianko S" first="Stephen" last="Pianko">Stephen Pianko</name>
</noRegion>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Diago, Moises" sort="Diago, Moises" uniqKey="Diago M" first="Moises" last="Diago">Moises Diago</name>
</region>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Foster, Graham R" sort="Foster, Graham R" uniqKey="Foster G" first="Graham R." last="Foster">Graham R. Foster</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Benhamou, Yves" sort="Benhamou, Yves" uniqKey="Benhamou Y" first="Yves" last="Benhamou">Yves Benhamou</name>
</region>
</country>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3

Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3

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